PathAI and Aster Insights Partner to Deliver Combined AI-Derived Structured Pathology and Multimodal Real-World Data Solutions

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PathAI, a global leader in AI-powered pathology, and Aster Insights, the leading provider of scientific and clinical intelligence for oncology discovery, today announced a multi-year strategic partnership to develop curated multimodal datasets that pair PathAIs PathExplore¹ artificial intelligence (AI) tumor microenvironment (TME) quantification panel with Aster Insights Avatar clinical, molecular, and digital pathology imaging data. By combining their respective best-in-class platforms, PathAI and Aster Insights will be able to expedite the development of novel insights to accelerate the discovery and development of new treatments for patients with cancer.

The partnership will allow PathAI to utilize digital whole slide imaging (WSI) from Aster Insights Oncology Research Information Exchange Network (ORIEN). ORIEN members participate in Total Cancer Care (TCC), the worlds largest and longest-running observational research study in oncology, which has accrued over 400,000 patients to date.

Digital pathology images contain a wealth of untapped data, and PathAIs PathExplore is the worlds first structured, standardized, and scalable product that leverages AI to characterize the TME from routinely available hematoxylin and eosin (H&E) stained digital WSIs. PathExplore exhaustively detects and classifies the millions of cell and tissue regions across H&E WSIs to provide researchers access to important insights, such as patterns of immune cell infiltration and presence of complex tissue structures. These data are critical for better understanding existing treatments and the development of novel therapeutics.

PathExplore features are paired with Asters Avatar multimodal data including tumor whole exome and whole transcriptome sequencing, which allows researchers to follow a patient throughout their cancer journey and access rich information about their cancer biology. Avatar provides a powerful set of data, allowing for a deeper understanding of disease pathology, and what happens to patients when they are exposed to certain treatments.

Analysis of histopathology images uniquely allows researchers to define and quantify spatial changes in the tumor microenvironment resulting from treatment or disease progression, said Andy Beck, M.D., Ph.D., Chief Executive Officer and Co-founder of PathAI. Our collaboration with Aster Insights is empowering researchers with robust multimodal datasets to explore hypotheses such as identifying and analyzing novel histological biomarkers correlated with patient treatment, outcomes, and gene expression.

Our approach to leveraging AI with multimodal data will lead to new information and deeper insights than currently possible, said Anand Shah, M.D., Chief Executive Officer of Aster Insights. Together with PathAI, we are creating new knowledge that is critical for researchers and life sciences partners to expand therapeutic options.

PathAI and Aster Insights are offering these joint solutions to biopharma customers to support targeted and pan-cancer initiatives across the drug development lifecycle. For more information, please contact Aster Insights and PathAI. You can also connect with both companies at ASCO in Chicago, IL, from May 31-June 4, 2024.

Footnotes

¹PathExplore is For Research Use Only. Not for use in diagnostic procedures.

About PathAI

PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials to the industry leading AISight Image Management System. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge biomarker status and accelerate drug development for complex diseases. For more information, please visit www.pathai.com.

About Aster Insights

Aster Insights is the leading provider of scientific and clinical intelligence for oncology discovery. We partner with drug, biologics, diagnostics, and medical device developers to accelerate oncology product discovery and development. Aster Insights leads the Oncology Research Information Exchange Network (ORIEN), a consortium of the nation's leading cancer centers that conduct Total Cancer Care, the world's largest and longest running observational research study in oncology. Together, we are changing the way cancer is studied, treated, and prevented. Learn more at www.AsterInsights.com and follow us on LinkedIn and Twitter.